LCR35 LIVE BIOTHERAPEUTIC MICROORGANISM MECHANISM-OF-ACTION ON CANDIDA ALBICANS

Objectives:

    - Screening of antimicrobial proteins to define the mechanism of action of Lcr35®.
    - Exploration of the mode-of-action of the identified anti-Candida compounds.
    - LBP and isolated antimicrobial proteins impact on host immunity in a Caenorhabditis elegans model.
    - Development of a new LBP optimizing the anti-Candida activity for intestinal and/or vaginal and other applications (topic, systemic).

Expected Results:

    - Determination of the anti-Candida molecule(s) secreted by Lcr35®
    - Understanding and characterization of the involved metabolic pathway
    - Development of LBP to promote this metabolic pathway and improve anti-Candida activity

PROJECT SUPERVISOR:

KARINE ROGET

INSTITUTION:

Biose