The main goal of the FunHoMic project is to train 13 innovative, entrepreneurial and creative ESRs through our interdisciplinary and inter-sectoral research programme, which is based on our working hypothesis that susceptibility to fungal infections can be strongly influenced by the Fungal-Host-Microbiota interplay.
This goal will be achieved through specific scientific objectives:
Establish new bioinformatic, organ-on-chip and gut simulation approaches to enhance the existing toolkit used to dissect the fungal-host-microbiota interplay during commensalism and pathogenicity (Work Package 1).
Understand how C. albicans genetic variability impacts the fungal cell surface and metabolic adaptation to host niches and how this correlates with infectivity (Work Package 2).
Explore how simultaneous variations of the host and microbiota influence C. albicans genetics and virulence to identify biomarkers of infection outcome (Work Package 3).
Investigate and exploit the mechanisms by which specific bacteria in the microbiota, including novel LBP candidates, impact C. albicans infectivity (Work Package 4).
The research structure of FunHoMic: Research Work Packages (WP 1-4) plus integrated Work Packages for Training (WP5), Exploitation and Dissemination (WP6) and Management (WP7)