INTEGRATION OF MICRO AND MYCOBIOME SEQUENCE DATA

Objectives:

    - To build a gene catalogue that will serve as a reference database for human fungi in mycobiota analysis
    - To explore the Fungal-Host-Microbiota interplay by integrating both bacterial and fungal components of the microbiota at DNA and RNA levels
    - To evaluate whether specific myco- and microbial signatures in the GI or vaginal tract correlate with variable levels of colonization by Candida, host antifungal response and recurrence of vaginal infection.

Expected Results:

    - Development of bioinformatics pipeline and construction of gene catalogue
    - Integration of micro- and mycobiome to understand bacteria-fungi interaction and assess the impact of the microbiotahost interplay on the severity of fungal infection