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In 2006, Dr. Manichanh joined the VHIR institute in Barcelona as principal investigator to pursue her line of research on Human Microbiome. Since 2002, she is using meta-omic approaches to study the human microbiome associated with disorders. She has collaborated with the MetaHIT and the IHMS European consortia to build a comprehensive gene catalogue from the human gut microbiome and to develop standard operating procedures (SOPs) and protocols in order to optimize data comparisons in the human microbiome field. With this experience and her double expertise in molecular microbiology (PhD University Paris VI, 2001) and in bioinformatics (Diplôme d'Informatique en biologie at Institut Pasteur, Paris 2000), she is leading at VHIR a multidisciplinary research group to develop molecular, cellular as well as bioinformatics tools to understand the role of the microbiome in human health and disease.


Selected publications:

  • Santiago A, Sanchez E, Clark A, Pozuelo M, Calvo M, Yañez F, Sarrabayrouse G, Perea L, Vidal S, Gallardo A, Guarner C, Soriano G*, Chaysavanh Manichanh C*. 2019
    Sequential changes in the mesenteric lymph node microbiome and immune response during cirrhosis induction in rats.
    mSystems (In press).

  • Costea et al. (IHMS consortium, including Manichanh C). 2017
    Towards standards for human fecal sample processing in metagenomic studies.
    Nature Biotechnology (PMID: 28967887).

  • Pascal V, Pozuelo M,  Borruel N, Casellas F, Campos D, Santiago A, Martinez X, Varela E, Sarrabayrouse G, Machiels K, Vermeire S, Sokol H, Guarner F and Manichanh C*. 2017
    A Microbial Signature for Crohn’s Disease. 
    Gut (PMID: 28179361).

  • Plichta D, Juncker A, Bertalan M, Rettedal E, Gautier L, Varela E, Manichanh C, Fouqueray C, Levenez F, Nielsen T, Doré J, Dantas Machado A, Evgrafov M, Hansen T, Jørgensen T, Bork P, Guarner F, Pedersen O, Sommer M, Ehrlich D, Sicheritz-Pontén T, Brunak S, Nielsen HB. 2016
    Transcriptional interactions suggest niche segregation among microbes in the human gut.
    Nature Microbiology (PMID: 27564131)

Supervised Projects:

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