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ASSESSMENT OF THE SECRETED METABOLOME IN CANDIDA ALBICANS
Objectives:
- - Assess the secreted metabolome of C. albicans isolates in correlation with strain virulence and/or other relevant phenotypes, using metabolic fingerprinting and untargeted metabolomics/lipidomics approaches
- Investigate by metabolic imaging host-fungus interactions and associated metabolite production
- Perform genotype-phenotype association studies in order to identify the genetic basis for variation in relevant metabolite production
- Evaluate the presence of selected metabolites in the bloodstream/stools of infected animals
Expected Results:
- - A description of the secreted metabolome of C. albicans related to virulence and other relevant phenotypes and its variation across isolates and during infection
- A definition of genetic variants underlying variations in the secretion of metabolites by C. albicans
- An evaluation of the presence of selected metabolites in sera/stools of mice infected by C. albicans
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