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English / Mandarin

My part in this network is “to expand the bioinformatics toolkit for studying the Fungus-Host-Microbiota interplay” by integrating sequence and clinical data obtained from fecal and vaginal samples collected from volunteers. This work is based in the microbiome lab of Vall d’Hebron Research Institute (VHIR), a multidisciplinary biomedical research public center that promotes and develops innovative biomedical research in Barcelona.


As has been described in the whole project, the aim of FunHoMic is to study the interaction between three key players that influence the severity of the fungal infection: the fungus itself, the host and the microbiota. While analysis of the bacterial microbiota has become routine, that of the fungal microbiota – mycobiota -- is still hampered by the lack of robust fungal databases and efficient analytical pipelines.


My thesis will dedicate to the development of databases and pipelines for the simultaneous analysis of bacterial and fungal components of the microbiota, including several main objectives:
• To standardize the routine of analyzing human fungi, from genetic samples extraction to bioinformatic and statistical processing of generated sequencing datasets
• To build a gene catalogue that will serve as a reference database for human fungi in mycobiota analysis
• To explore the Fungus-Host-Microbiota interplay by integrating both bacterial and fungal components of the microbiota at DNA and RNA levels
• To evaluate whether specific myco- and microbial signatures in the GI or vaginal tract correlate with variable levels of colonization by Candida, host antifungal response and recurrence of vaginal infection

At the end, we hope that this my project could help to improve the normalization of human fungal analysis and to assess the impact of the microbiota-host interplay on the severity of fungal infection.

我在这个联合研究会中的工作主要是通过收集志愿者的粪便和阴道微生物样本,并整合从中获得的序列和临床数据,从而来扩展用于研究真菌-宿主-微生物群落相互作用的生物信息学工具。这部分工作主要在西班牙巴塞罗那Vall d’Hebron研究所(VHIR)的微生物组实验室进行,该实验室是一个跨学科的生物医学研究公共中心,致力于在巴塞罗那促进生物医学的创新研究。

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