Prof. Dr. Bernhard Hube is the Head of Department of Microbial Pathogenicity Mechanisms at HKI and Chair for Microbial Pathogenicity at Friedrich Schiller University Jena.
Research Interests: Molecular biology of human pathogenic fungi (Candida albicans, C. glabrata); functional genomics; host/pathogen interactions; ex vivo / in vitro infection models; extracellular enzymes; regulatory proteases; infection associated genes; iron acquisition; intracellular survival; invasion mechanisms; microevolution; morphology, mode of action of antifungal agents, toxins.
Education and scientific career: PhD and post-doctoral training (University Goettingen); Honour Research Fellow (University of Aberdeen); Postdoc and then Assistant Professor (University of Hamburg); Head of Division “Mycology” (Robert Koch Institute, Berlin); Professor of Microbial Pathogenicity (Friedrich Schiller University, Jena).
Kasper L, König A, König PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, and Hube B (2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nature Communication 15;9(1):4260.
Allert S & Förster TM, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S and Hube B. (2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9(3). pii: e00915-18. (IF 2015: 6.88) Publication award 2018 of the German Speaking Mycological Society (DMYKG); Paper of the Month August 2018 by the German Society for Hygiene and Microbiology (DGHM)
Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krueger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B*, Naglik JR (2016) Candidalysin: A fungal peptide toxin critical for mucosal infection. Nature 532, 64-68. (IF 2013: 38.14)
*corresponding author. Selected by Faculty 1000 (3x), comments in Nature and Nature Review Microbiology, “Paper of the month - April 2016” of the DGHM, Leibniz Drug of the Year Award 2017, Medac Award 2017, Beutenberg Campus Award 2018
Microbial Pathogenicity Mechanisms