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ESR 9 - Diletta Rosati

Principal investigator: Mihai Netea

Host institution: Radboudumc

ESR Project





Microbiome and host genetics interaction in the susceptibility to recurrent vulvo-vaginal candidiasis

In 2016, I obtained my bachelor degree in Biotechnologies discussing a thesis entitled “LMW-PTP and chemoresistance: a new possible therapeutic approach " under the supervision of Professor Giovanni Raugei at the Department of Biochemical Sciences (Florence, Italy).

I realized I had a keen interest in molecular research, which is why I enrolled to the Master’s programme “Molecular Biotechnology” at the University of Florence in 2016. I obtained my masters in 2018 with a dissertation titled “Toll-like receptor 10, a new player in the arena of Lyme-associated joint inflammation” supervised by Professor Duccio Cavalieri. The master’s thesis was part of a broad research project carried out at the Department of Experimental Internal Medicine at the Radboudumc in Nijmegen (The Netherlands) under the supervision of Prof. L.A.B Joosten and Prof. Mihai Netea. The supervision of Professor Duccio Cavalieri, focused mainly on yeast biology and microbiology, and the internship at the Experimental Internal Medicine Department made me more interested to focus my research career on infectious diseases in Immunology. In general and in particular how the host immune system responds to infections by different pathogens.

Since April 1st 2019, I joined the Experimental Internal Medicine Department at the Radboudumc in Nijmegen (Prof. Mihai Netea) as ESR9 to work on the FunHoMic project. The aim of the project is to understand the interaction between the fungus-host-microbiota interplay at the level of mucosa, more specifically novel factors and pathways in order to decipher how these affect susceptibility to recurrent vulvo-vaginal candidiasis (RVVC). These new insights may lead to a better understanding of the pathogenesis in RVVC as well as the development of novel treatment strategies.