Objectives:

• To understand the impact that the interaction between the host genome and microbiome (both bacteriome and mycobiome) has on the antifungal host defense at the level of mucosa
• To decipher how this affects susceptibility to recurrent vulvo-vaginal candidiasis (RVVC).

Expected Results:

• Identification of the microbiome and genomic factors influencing mucosal anti-fungal responses 
• Novel factors which drive susceptibility to RVVC will be found
• The microbiome components that modulate susceptibility and disease outcome in patients with RVVC will be identified