Skip to main content
x

Objectives:

  • Assess the secreted metabolome of C. albicans isolates in correlation with strain virulence and/or other relevant phenotypes, using metabolic fingerprinting and untargeted metabolomics/lipidomics approaches
  • Investigate by metabolic imaging host-fungus interactions and associated metabolite production
  • Perform genotype-phenotype association studies in order to identify the genetic basis for variation in relevant metabolite production
  • Evaluate the presence of selected metabolites in the bloodstream/stools of infected animals 

Expected Results:

  • A description of the secreted metabolome of C. albicans related to virulence and other relevant phenotypes and its variation across isolates and during infection
  • A definition of genetic variants underlying variations in the secretion of metabolites by C. albicans
  • An evaluation of the presence of selected metabolites in sera/stools of mice infected by C. albicans

     

 

PROJECT SUPERVISOR
Vincent Thomas

 

 

POSITION FILLED

 

Project Description